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The duration of the intraocular pressure-lowering effect after the inhalation of marijuana is indeed around 4 hours, which aligns with the pharmacological properties of cannabinoids. Tetrahydrocannabinol (THC), the primary psychoactive component in marijuana, interacts with cannabinoid receptors in the central nervous system, leading to a reduction in intraocular pressure (IOP).

Research has shown that the effects of inhaled THC can improve IOP for a substantial period, often cited at around 3 to 4 hours. This duration is significant because individuals seeking therapeutic benefits, such as those with glaucoma, may find a 4-hour effect to be clinically relevant for managing their condition.

It's important to note that the medical application of marijuana and cannabinoids for ocular conditions is still under study, with varied responses based on individual patient factors and delivery methods. Understanding the duration of IOP effects helps in considering treatment regimens and the potential need for additional interventions or medications within that timeframe.