Ace the NBEO Pharmacology Exam 2026 – Dive Deep and Dose Up Your Success!

Excessive use of Chloroquine is associated with a specific retinal toxicity known as bull's eye maculopathy. This condition is characterized by a distinctive pattern of damage that occurs in the macula, the central portion of the retina responsible for sharp vision.

In bull's eye maculopathy, there is an accumulation of the drug in the retinal pigment epithelium, leading to retinal cell damage. The appearance is typically that of a central area of sparing surrounded by concentric rings of pigmentary changes, which corresponds to the pattern described as a "bull's eye." This vision-threatening condition can lead to significant visual impairment if not recognized and addressed.

Monitoring patients on long-term Chloroquine therapy is crucial to prevent the progression of this maculopathy, and regular eye examinations are recommended to detect any early signs of retinal toxicity. Understanding this adverse effect is essential for healthcare providers managing patients who require Chloroquine for conditions such as malaria or autoimmune disorders.